Rejuran vs Profhilo in Seoul

What are Rejuran and Profhilo?

Rejuran Healer is a Korean skin booster made from polynucleotides (PN) purified from salmon DNA. Profhilo is an injectable made of a high concentration of stabilised hyaluronic acid (HA) that spreads under the skin. Both are injected in small amounts to improve skin quality rather than to add shape or volume.

What is the key difference?

Rejuran is injected as many tiny blebs across the face, where PN is thought to support the skin's repair process, improving texture, pores and fine lines. Profhilo is placed at a few fixed points on each side of the face and spreads through the upper fat and dermis, binding water and stimulating the skin over time. The key difference is that Rejuran targets repair and texture, while Profhilo targets hydration, glow and mild firmness.

Which one should you choose?

Choose Rejuran if you have enlarged pores, rough texture or fine acne scars
Choose Rejuran if your skin is sensitive or recovering after lasers
Choose Profhilo if your main issue is dry, dull or crepey skin
Choose Profhilo if you want fewer injection points and less visible bumps
Choose either one as maintenance for skin quality in your 30s to 50s

When neither is the right fit

Pregnant or breastfeeding people
Anyone with active skin infection, cold sores or acne flare at the site
People with a fish or salmon allergy (Rejuran)
People who need volume or lifting rather than skin quality
Anyone with a known allergy to hyaluronic acid products or lidocaine

What happens at the appointment

Consultation to decide which booster suits your skin concern
Cleansing and numbing cream for 20–40 minutes
Injections: many small points for Rejuran, a few fixed points for Profhilo
Cooling or a soothing mask to calm the skin
Aftercare advice and booking the next session if needed

Aftercare and flying home

Expect small bumps for 1–3 days after Rejuran; they settle on their own
Avoid makeup for about 12–24 hours
Skip saunas, intense exercise and alcohol for 1–2 days
Do not massage or press the treated area for a day
Use gentle skincare and daily sunscreen

Side effects and risks

Redness, swelling and small raised bumps at injection points
Bruising, which can last up to a week
Temporary tenderness or stinging, as Rejuran can be uncomfortable
Rare allergic reaction or infection

Costs in Seoul

Rejuran ₩200K–500K · Profhilo ₩300K–700K (about US$150–500 per session) — Rejuran prices in Seoul depend on the product version (Healer, Eye, S), the amount in cc and the number of areas treated. Profhilo is imported and priced per syringe, so it usually costs more per session. All prices here are estimates and change often with package deals and promotions.

Why visitors choose Seoul

Rejuran was developed in Korea and is widely used in Seoul clinics, so prices are lower and practitioners are very experienced with it. Profhilo is also available, which makes it easy to compare both in one consultation or combine them in a package.

Frequently asked questions

How much do Rejuran and Profhilo cost in Seoul?

Rejuran usually costs about ₩200,000–₩500,000 per session and Profhilo about ₩300,000–₩700,000 per syringe. Packages of several sessions often lower the price per visit.

Which hurts more, Rejuran or Profhilo?

Rejuran is usually more uncomfortable because it uses many injection points and the product can sting. Profhilo uses fewer points, so most people find it easier, especially with numbing cream.

How many sessions of Rejuran or Profhilo do I need?

Rejuran is usually done as 3 sessions about 2–4 weeks apart. Profhilo is usually 2 sessions about 4 weeks apart. Both are then repeated every 4–6 months for maintenance.

Can I fly home after Rejuran or Profhilo?

Yes, you can usually fly the next day. Rejuran bumps may still be visible for 1–3 days, so it is better done early in your trip.

Are Rejuran and Profhilo safe?

Both are widely used and generally well tolerated when injected by a trained doctor. Common side effects are bumps, redness and bruising; infection and allergy are rare.

Can I combine Rejuran and Profhilo?

Yes, some clinics combine them or alternate sessions, since they work in different ways. Ask the doctor to plan the timing and total amount so you do not over-treat the skin.