Salmon DNA Injection in Korea: What You Need to Know

What Is Salmon DNA Injection?

Salmon DNA injection, also known as PN (polynucleotide) or PDRN therapy, is a cutting-edge skin rejuvenation treatment that originated in Korea and has taken the global beauty world by storm. It uses highly purified DNA extracted from salmon sperm, which closely resembles human DNA and has remarkable healing, anti-inflammatory, and regenerative properties. Unlike traditional fillers or Botox, this injection focuses on repairing skin at the cellular level, boosting collagen, improving elasticity, and enhancing overall skin quality.

This treatment is often marketed under brand names like Rejuran Healer, but “salmon DNA injection” is the term most commonly recognized by global patients seeking natural, regenerative skincare in Korea.

How Does It Work?

The magic of salmon DNA lies in its ability to stimulate fibroblast activity, the cells responsible for producing collagen and elastin. When injected into the dermis, these polynucleotides repair damaged tissue, encourage new cell growth, and deeply hydrate the skin. Over time, skin becomes firmer, smoother, and more resilient — not because something is being added, but because your own skin is healing and strengthening itself from within.

This is what makes the treatment so popular among those who want natural anti-aging without volume, puffiness, or artificial results.

Why Is It So Popular in Korea?

Korea is renowned for being the global leader in advanced skincare, and salmon DNA injections are a staple in many Korean anti-aging programs. Here’s why the treatment is especially beloved in Seoul:

  • It offers a subtle, natural glow without changing your facial structure.
  • Minimal downtime makes it perfect for busy professionals and travelers.
  • It works well with other Korean skin treatments like laser toning, microneedling, and lifting.
  • Korean dermatologists and clinics have perfected the injection techniques to minimize pain and maximize results.

From K-pop idols to working professionals, this treatment is widely used across all age groups looking to improve their skin's baseline health.

Who Should Consider Salmon DNA Injection?

This treatment is ideal for:

  • People in their late 20s to 60s seeking preventative or regenerative anti-aging
  • Those suffering from dull, tired, or uneven skin tone
  • Individuals with acne scars or sensitive skin
  • Anyone looking to restore skin elasticity and hydration without fillers

It’s especially good for under-eye fine lines, laugh lines, neck skin, and areas with early wrinkling or sagging.

Whether you live in Korea or are visiting, this treatment is often part of long-term skin maintenance plans designed to help skin stay firm, smooth, and plump without appearing artificial.

Procedure Details: What to Expect

  • Treatment Time: 20–30 minutes
  • Anesthesia: Numbing cream applied beforehand
  • Discomfort: Mild pricking sensation
  • Recovery: Tiny red bumps for 1–2 days, makeup can be worn after 24 hours
  • Recommended Sessions: 3 sessions spaced 3–4 weeks apart, followed by maintenance every 6 months

Most patients report visible improvement in skin texture, moisture balance, and radiance within 2–4 weeks of the first session.

Cost of Salmon DNA Injections in Korea

In Seoul, the average cost for one session ranges between 250,000 to 500,000 KRW, depending on:

  • The reputation and location of the clinic (Gangnam clinics may charge more)
  • Whether additional skin boosters or lasers are combined
  • Whether the treatment uses Rejuran, Rejuran HB, or other enhanced formulations

Many clinics offer discounted packages if you book 3 sessions upfront — which is the most effective protocol.

Where to Get Salmon DNA Injection in Korea

Top locations include:

  • Gangnam: Home to premium dermatology and anti-aging clinics
  • Apgujeong: High-end aesthetic zones known for personalized skincare
  • Myeongdong: Popular with international patients, many clinics offer English-speaking services

When choosing a clinic:

  • Look for board-certified dermatologists or skin specialists with experience in injectables
  • Ask about Rejuran brands, technique (manual vs. injector gun), and aftercare
  • Check online reviews and before-after photos, especially from foreign patients

Reviews from Global Patients

Many international patients visiting Korea for this treatment describe it as:


“Like pressing the reset button on my skin.”
“It didn’t change how I looked — I just looked healthier and more refreshed.”
“It’s subtle, but people keep telling me my skin looks really good.”

Unlike volumizing fillers, the change isn’t dramatic overnight — but after a few weeks, your skin will look smoother, brighter, and more elastic. Most patients return for maintenance treatments once or twice a year.


Final Thoughts

Salmon DNA injection is one of Korea’s most trusted anti-aging and skin-healing treatments — backed by science, trusted by dermatologists, and beloved by patients who want to look younger without looking done. If you’re visiting Korea and want to treat your skin to a gentle but powerful upgrade, salmon DNA may be your secret weapon.

Whether you’re looking to treat fine lines, improve skin texture, or just get your glow back, this natural injectable can help revive your skin from within.