Treatment guide · Skin Boosters

Nucleofill in Seoul

A polynucleotide skin booster in several strengths for fine lines, firmness and under-eye skin.

Ask the clinic for: 뉴클레오필 (PN 스킨부스터)

Nucleofill explained

Nucleofill is a skin booster made in Italy from polynucleotides. It comes in several strengths, such as softer versions for the eye area and stronger versions for firmness. It is used for fine lines, crepey skin and dull texture.

How Nucleofill works

The polynucleotide gel is injected into the dermis as small drops or short lines. Polynucleotides hold water and are thought to support fibroblasts, which make collagen and elastin. The skin becomes smoother and firmer over a few weeks. The doctor chooses the strength based on skin thickness and area.

Who Nucleofill is for

• Fine lines and crepey skin
• Thin skin under the eyes
• Neck and décolletage texture
• Skin that looks tired or dull
• Support after laser or resurfacing

Who should avoid Nucleofill

• Pregnant or breastfeeding women
• People with a fish allergy, since polynucleotides are often fish-derived
• Active infection, acne or rash at the site
• Anyone wanting lifting or volume

What happens at the appointment

1. Consultation to pick the strength and area
2. Cleansing and numbing cream
3. Small injections across the area
4. Cool pack or soothing mask
5. Aftercare advice and scheduling

Aftercare and flying home

• Avoid makeup for 12–24 hours
• Skip saunas, alcohol and hard workouts for 1–2 days
• Do not rub the area for a few days
• Use sunscreen daily

Side effects and risks

• Small bumps for 1–2 days
• Redness and pinpoint bruises
• Swelling, more often under the eyes
• Rarely, allergy or infection

How much does Nucleofill cost in Seoul?

₩200,000–₩550,000 (about US$150–400) — Nucleofill is imported, so in Seoul it often costs more than Korean PN brands. Price depends on the strength, the number of syringes and the areas treated. Prices are estimates and change with promotions.

Why get Nucleofill in Korea?

Seoul clinics use polynucleotide boosters very often, so injection technique is well practised. Visitors can compare imported and Korean PN options in one consultation.

Frequently asked questions

How much does Nucleofill cost in Seoul?

Nucleofill usually costs about ₩200,000–₩550,000 per session in Seoul. Under-eye or full-face treatments with more product cost more.

Does Nucleofill hurt?

It feels like small pinches with mild stinging. Numbing cream helps a lot.

How many Nucleofill sessions are needed?

Most people have 3 sessions 2–3 weeks apart. Results usually last 4–6 months.

Can I fly after Nucleofill?

Yes, flying is fine soon after. Small bumps or bruises may still show for 1–2 days.

Is Nucleofill safe?

It is generally low risk in trained hands. Tell the doctor about any fish allergy before treatment.

Is Nucleofill better than Rejuran?

Neither is clearly better for everyone. Both are polynucleotide boosters, and the choice often comes down to price, availability and the doctor's preference.

Where to get it in Seoul

Foreigner-friendly clinics cluster around Gangnam, Sinsa–Apgujeong–Cheongdam and Myeongdong. Tap a number to zoom in, then tap a pin to ask the clinic on WhatsApp whether they offer this treatment and for a quote.